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Zinc Finger MYND Domain Containing Protein-1
Definition and Synonyms

Definition: Expressed in testis and skeletal muscle by human SMYD3 Gene, 428-aa 49-kDa Zinc Finger MYND Domain Containing Protein 1 is a CCCTCC promoter-binding histone methyltransferase and transcriptional regulator that contains an N-terminal MYND-type zinc finger domain followed by a SET domain. Cytoplasmic at G0/G1 and nuclear at S and G2/M, SMYD3 appears to enhance cell proliferation. Through interaction with RNA helicase HELZ, SMYD3 forms a complex with RNA polymerase II. Enhanced by heat-shock protein HSP90A, the SET domain shows histone H3 lys4-specific methyltransferase activity and transcriptional activation of oncogenes, homeobox genes, and cell-cycle regulation genes. (NCI)

Synonyms: Zinc Finger MYND Domain Containing Protein 1, SET and MYND Domain Containing 3, SET and MYND Domain Containing Protein 3, SMYD3, Zinc Finger MYND Domain Containing 1, Zinc Finger Protein Subfamily 3A (MYND Domain Containing) 1

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