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XDH Gene
Definition and Synonyms

Definition: This gene encodes xanthine dehydrogenase, which involved in the oxidative metabolism of purines. The XDH gene contains 36 exons and spans at least 60 kb. Its gene product can be converted to xanthine oxidase by reversible or irreversible reactions. The amino acids sequences involved in both reversible or irreversible conversions are completely conserved between rat and human enzymes. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. (NCI)

Synonyms: XDH Gene, XD, XO, XOR, Xanthine Dehydrogenase Gene

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