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T-Cell Receptor-T3 Gamma Chain
Definition and Synonyms

Definition: Encoded by human CD3G Gene, 182-aa 20.5-kDa (precursor) T-Cell Receptor-T3 Gamma Chain is a cell surface type I membrane protein similar to CD3D containing an Ig-like domain and a ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement with MHC-associated antigen on host cell surfaces, CD3 activity leads to T-cell activation. CD3G defects are associated with T cell immunodeficiency. (NCI)

Synonyms: T-Cell Receptor T3 Gamma Chain

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