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T-Cell Receptor-T3 Delta Chain
Definition and Synonyms

Definition: Encoded by CD3D Gene, 171-aa 19-kDa (precursor) T-Cell Receptor-T3 Delta Chain is a cell surface type I membrane protein containing 1 ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 complex plays an important role in the developmental transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes in the thymus that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement, CD3D activity leads to tyrosine-phosphorylated CD3Z, tyrosine phosphorylation of colocalized LAT in lipid rafts, MAPK3 or MAPK8 activation, and positive selection. (NCI)

Synonyms: T-Cell Receptor T3 Delta Chain, CD3 Delta, CD3D, T-Cell Surface Glycoprotein CD3 Delta Chain, T3D, TiT3 Complex CD3D Antigen Delta Polypeptide

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