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Nutrtion Guide Home > NCI Cancer Thesaurus > Ubiquitin-C

Ubiquitin-C
Definition and Synonyms

Definition: Encoded by human UBC Gene, highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin C is synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins typically appear to be covalently bound to proteins as a marker for degradation, but may participate in other cellular functions as well. (NCI)

Synonyms: Ubiquitin C, UBC

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