Nutrtion Guide Home > NCI Cancer Thesaurus > UBC Gene

UBC Gene
Definition and Synonyms

Definition: Consisting of 9 ubiquitin repeats in the coding sequence, human UBC Gene encodes highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin C, synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins typically appear to be covalently bound to proteins as a marker for degradation, but may participate in other cellular functions as well. Polyubiquitin genes comprise tandem ubiquitin repeats in the coding unit, while ubiquitin fusion genes encode a single ubiquitin fused to an unrelated tail protein. (NCI)

Synonyms: UBC Gene, HMG20, UBC

To search for UBC Gene on the web, just click the search button below.

Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.

A | B | C | D | E | F | G | H | I | J | K | L | M
N | O | P | Q | R | S | T | U | V | W | X | Y | Z