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Ubiquitin-B
Definition and Synonyms

Definition: Encoded by human UBB Gene, highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin B is synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. UBB appears to be covalently bound to proteins as a marker for degradation, but also binds to histone H2A in actively transcribed regions and does not cause histone H2A degradation; UBB may be involved in regulation of gene expression. (NCI)

Synonyms: Ubiquitin B, Polyubiquitin B, UBB

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