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I-Kappa-B-Epsilon Protein
Definition and Synonyms

Definition: Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI)

Synonyms: I-Kappa-B-Epsilon, IKB-Epsilon, IKBE, NF-Kappa B Inhibitor Epsilon, NF-Kappa-B IE, NFKBIE, Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Epsilon

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