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G-i Alpha-1 Protein
Definition and Synonyms

Definition: Expressed as at least 2 classes (brain and monocyte) by human GNAI1 Gene (G-Alpha 1 Family), 353-aa 40-kDa G(i) Alpha 1 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. GNAI1 is the predominant alpha(i) of brain. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI)

Synonyms: G(i) Alpha 1 Protein, Adenylate Cyclase-Inhibiting G Alpha Protein, G Protein Alpha Inhibiting Activity Polypeptide 1, GNAI1, Gi1 Protein Alpha Subunit, Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 1, Guanine Nucleotide-Binding Protein G(i) Alpha-1 Subunit

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