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IFNGR2 Gene
Definition and Synonyms

Definition: Expressed from multiple transcription start sites (absent TATA and CAAT boxes), 33-kb 7-exon human IFNGR2 Gene (Type II Cytokine Receptor Family), encodes 337-aa 38-kDa (precursor) type I membrane protein Interferon Gamma Receptor Beta Chain, an integral accessory factor subunit of Interferon Gamma Receptor Complex required for signal transduction. Ser/Thr phosphorylated IFN Gamma Receptor activates macrophages in innate immune responses to viral infection and host defenses. Ligand-bound receptor activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain. Containing 2 fibronectin type III domains, IFNGR2 may interact with GAF, JAK1, and/or JAK2. (NCI)

Synonyms: IFNGR2 Gene, IFNGR2, IFNGT1

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