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IFNGR1 Gene
Definition and Synonyms

Definition: Expressed as a 2.3-kb transcript in monocytes, lymphocytes, and placenta, human IFNGR1 Gene (Type II Cytokine Receptor Family) encodes monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain, a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI)

Synonyms: IFNGR1 Gene, IFNGR, IFNGR1

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