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IFNAR2 Gene
Definition and Synonyms

Definition: Human IFNAR2 Gene (Type II Cytokine Receptor Family) encodes 515-aa 58-kDa (precursor), 331-aa, and 515-aa isoforms of ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Beta Chain, the beta subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. IFNAR2 interacts with RACK1. (NCI)

Synonyms: IFNAR2 Gene, IFNAR2, IFNARB

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