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IFNAR1 Gene
Definition and Synonyms

Definition: Human IFNAR1 Gene (Type II Cytokine Receptor Family) encodes 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain, containing 3 fibronectin type III domains and the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)

Synonyms: IFNAR1 Gene, IFNAR, IFNAR1

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