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N-Myc Downstream Regulated Protein-1
Definition and Synonyms

Definition: Expressed most prominently in placenta, prostate, kidney, small intestine, and ovary, human NDRG1 Gene (NDRG Family, Alpha/Beta Hydrolase Superfamily) encodes ubiquitous cytoplasmic N-Myc Downstream Regulated Protein 1, also associated with the plasma membrane and nucleus. Downregulated by NMYC and rapidly induced by okadaic acid, a serine/threonine phosphatase inhibitor, increased NDRG1 levels are induced by an elevation of free intracellular calcium ion; cells that border lumenae show highest expression. Involved in stress responses, hormone responses, cell growth, and differentiation, NDRG1 may have a growth inhibitory role. (NCI)

Synonyms: N-Myc Downstream Regulated Protein 1, CAP43, DRG1, Differentiation-Related Gene 1 Protein, NDR1, NDRG1, NDRG1 Protein, Nickel-Specific Induction Protein CAP43, Protein Regulated By Oxygen-1, RIT42, RTP, Reducing Agents and Tunicamycin-Responsive Protein, Tunicamycin-Responsive Protein

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