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S-Phase Kinase-Associated Protein-2
Definition and Synonyms

Definition: Expressed by human SKP2 Gene (F-Box Family) as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), S-Phase Kinase-Associated Protein 2 contains an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI)

Synonyms: S-Phase Kinase-Associated Protein 2, CDK2/Cyclin A-Associated Protein p45, Cyclin A/CDK2-Associated Protein p45, F-Box Protein SKP2, SKP2, p45 SKP2

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