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Jumping Translocation Breakpoint Protein
Definition and Synonyms

Definition: Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. The JTB gene (jumping translocation breakpoint) is found fused with the telomeric repeats of acceptor telomeres in a case of jumping translocation. Jumping Translocation Breakpoint is encoded by this open reading frame, and is highly conserved among divergent eukaryotic species. JTB is a 146-aa protein with a 75-aa extracellular domain, a 21-aa transmembrane domain, and a 20-aa intracellular domain. Jumping translocations have been reported in leukemia patients, in the Ewing family of tumors, in renal clear cell carcinoma, and in liposarcoma. (from OMIM)

Synonyms: Jumping Translocation Breakpoint Protein, JTB, JTB Protein, PAR Protein, Prostate Androgen Regulated Protein

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