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Zolimomab Aritox
Definition and Synonyms

Definition: An immunotoxin consisting of a murine anti-CD5 monoclonal antibody conjugated to the ricin A chain. The anti-CD5 monoclonal antibody component binds to CD5, a T-cell associated antigen, thereby targeting the delivery of the cytotoxic ricin A chain to T-cells. The ricin A chain component binds to T-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)

Synonyms: Zolimomab Aritox, Anti-CD5 MoAb, Anti-CD5 T-Lymphocyte Immunotoxin, Anti-T-Cell RTA Immunotoxin, Anti-T-Cell Ricin A Chain Immunotoxin, CD5-Immunoconjugate, H65-RTA, Orthozyme-CD5 Plus, Xomazyme CD5 Plus

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