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ZNF145 Gene
Definition and Synonyms

Definition: Induced by retinoic acid in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung, human ZNF145 Gene (Krueppel Family) encodes alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc Finger Protein 145, a probable transcription factor containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11;17)(q32;q21) involves ZNF145 and RARA. (NCI)

Synonyms: ZNF145 Gene, PLZF, ZNF145

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