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MAD Gene
Definition and Synonyms

Definition: The MAD gene at 2p13-p12 encodes MAX Dimerization Protein 1, which belongs to a subfamily of MAX-interacting proteins. MAD competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex. MAD acts as a transcriptional repressor while MYC appears to function as an activator) and is a candidate tumor suppressor gene. (from LocusLink and NCI)

Synonyms: MAD Gene, MAD, MAD Protein (MAX-Binding Protein) Gene, MAX Dimerization Protein Gene, MAX Dimerizer Gene, MXD1 Gene

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