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ID2 Gene
Definition and Synonyms

Definition: Highly expressed in most fetal tissues, the 15-kD human ID2 Gene (bHLH/ID Family) at 2p25 encodes 134-aa nuclear ID2 Protein, an HLH protein lacking a basic DNA-binding domain that heterodimerizes through the HLH domain with, and inhibits DNA binding of, other bHLH transcription factors in a dominant-negative manner by suppressing their heterodimerization with functional partners. ID proteins promote cell proliferation and likely influence of cell differentiation. ID2 inhibits antiproliferative effects of active, hypophosphorylated RB, p107, and p130 tumor suppressor proteins, allowing cell cycle progression. By inactivating RB, ID2 also abolishes p16 growth inhibitory protein function. During normal cell cycle, RB inhibits ID2 action on its targets. MYC activates ID2 transcription. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Synonyms: ID2 Gene, ID2, MGC26389

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