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JAW1-Related Protein
Definition and Synonyms

Definition: The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. This protein is an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM)

Synonyms: JAW1-Related Protein, Inositol 1,4,5-triphosphate-associated cGMP Kinase Substrate, MRVI1

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