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Janus Kinase-3
Definition and Synonyms

Definition: This protein is a member of janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). (from LocusLink)

Synonyms: Janus Kinase 3, JAK3

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