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ZAP-70 Gene
Definition and Synonyms

Definition: Expressed in T- and NK cells, human ZAP-70 Gene (SYK/ZAP70 Family) encodes 619-aa 70-kDa Zeta-Chain Associated Protein (tyrosine) Kinase, containing 2 SH2 domains that bind to tyrosine phosphorylated ITAM of the TCR zeta chain upon TCR stimulation, which mediates transduction of stimuli to cellular effectors in lymphocyte activation. Associated with the zeta chain, ZAP70 undergoes tyrosine phosphorylation following TCR stimulation; Tyr-319 phosphorylation is essential for full activity. Following TCR ligation, a CRKL/WIP/WASP complex is recruited by ZAP70 to lipid rafts and immunologic synapses. Phosphorylated ZAP70 interacts with CBL, SLA, and SLA2; the association probably leads to its destruction. ZAP70 defects cause Selective T-Cell Defect. (NCI)

Synonyms: ZAP-70 Gene, SRK, STD, ZAP-70

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