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IDEC-114 Monoclonal Antibody
Definition and Synonyms

Definition: A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. IDEC-114 monoclonal antibody binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). (NCI04)

Synonyms: IDEC-114 Monoclonal Antibody, anti-B7-1, anti-CD80

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