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G-Protein Alpha Subunit-I2
Definition and Synonyms

Definition: Encoded by single copy human GNAI2 Gene (G-Alpha 1 Family), 354-aa 40-kDa G(i) Alpha 2 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI2 mutations affect cell proliferation. (NCI)

Synonyms: G(i) Alpha 2 Protein, G-Protein Alpha Subunit I2, GNAI2, Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 2

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