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Ubiquitin Ligase Gene
Definition and Synonyms

Definition: Ubiquitin Ligase Genes encode eukaryotic enzymes (Ubiquitin Ligases) involved in de/ubiquitination of cellular proteins with ubiquitin through its C-terminus. Regulating the half-lives of many proteins by targeting them for degradation, ubiquitination is associated with many regulated events including protein degradation, chromatin remodeling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. (NCI)

Synonyms: Ubiquitin Ligase Gene, Ubiquitin Ligase Component Gene

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