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C-C Motif Chemokine Receptor-8
Definition and Synonyms

Definition: Chemokine (C-C Motif) Receptor 8, encoded by the CCR8 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. (From LocusLink and NCI)

Synonyms: Chemokine (C-C Motif) Receptor 8, CCR8, CKR-L1, CKRL1, CMKBR8, CMKBRL2, CY6, Chemokine (C-C) Receptor 8, Chemokine (C-C) Receptor-Like 2, GPR-CY6, TER1

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