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C-C Motif Chemokine Receptor-5
Definition and Synonyms

Definition: Chemokine (C-C Motif) Receptor 5, encoded by the CCR5 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI)

Synonyms: Chemokine (C-C Motif) Receptor 5, C-C CKR-5, C-C Chemokine Receptor Type 5, CC-CKR-5, CCCKR5, CCR-5, CCR5, CCR5 Protein, CD195 Antigen, CHEMR13, CKR-5, CKR5, CMKBR5, Chemokine (C-C) Receptor 5, HIV-1 Fusion Co-Receptor

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