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Nutrtion Guide Home > NCI Cancer Thesaurus > UBE2D2 Gene

UBE2D2 Gene
Definition and Synonyms

Definition: Human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family) encodes 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2, which targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI)

Synonyms: UBE2D2 Gene, UBC4, UBCH5B, UBE2D2

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