Nutrtion Guide Home > NCI Cancer Thesaurus > XCL1 Gene

XCL1 Gene
Definition and Synonyms

Definition: Expressed (0.8-kb mRNA) in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary, 3-exon human XCL1 Gene (Intercrine Gamma Family) encodes 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1, similar to CCL8 and CCL3, but lacking the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)

Synonyms: XCL1 Gene, ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCYC1, XCL1

To search for XCL1 Gene on the web, just click the search button below.

Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.

A | B | C | D | E | F | G | H | I | J | K | L | M
N | O | P | Q | R | S | T | U | V | W | X | Y | Z