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RAD54B Gene
Definition and Synonyms

Definition: Highly expressed in testis and spleen as two alternative transcripts, human RAD54B Gene (SNF2/SWI2 Family) at 8q21.3-q22 encodes different isoforms of 910-aa 100-kD nucleoplasmic RAD54B Homolog, with significant homology to RAD54 and motifs similar to DNA and RNA helicases. RAD54B binds to double-stranded DNA and displays DNA-associated ATPase activity. RAD54B appears to associate indirectly with RAD51 through its N-terminal domain and may colocalize with RAD54 and BRCA1. Part of a complex involved in meiotic and mitotic homologous DNA recombination repair, RAD54B plays a critical role in targeted integration and recombination in concert with other RAD52 epistasis group members without affecting cell growth, sensitivity to DNA damaging agents, or sister chromatid exchange. (NCI)

Synonyms: RAD54B Gene, RAD54B

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