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IFNA13 Gene
Definition and Synonyms

Definition: Situated in a cluster of interferon-alpha and -omega genes and expressed by macrophages, the 0.65 kb human IFNA13 Gene (IFN Alpha Family) at 9p22 encodes a secreted 189-amino acid 21.7 kD Interferon Alpha 13 precursor containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Interferon Alpha 13 appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. Interferons Alpha-13 and Alpha-1 have identical protein sequence. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Synonyms: IFNA13 Gene, IFNA1, IFNA13

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