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F2R Gene
Definition and Synonyms

Definition: Expressed in platelets and vascular endothelia, human F2R Gene (GPCR1 Family) encodes 425-aa 47-kDa (precursor) Coagulation Factor II Receptor, a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desensitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand. (NCI)

Synonyms: F2R Gene, CF2R, F2R, PAR1, TR

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