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DAB2 Gene
Definition and Synonyms

Definition: The human tumor suppressor DAB2 Gene encodes Disabled Homolog 2 Protein, which is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Synonyms: DAB2 Gene, DAB2, DOC-2, DOC2

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