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X-Ray Repair Cross Complementing Protein-4
Definition and Synonyms

Definition: X-Ray Repair Cross Complementing Protein 4, encoded by the XRCC4 gene, functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. XRCC4 functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. XRCC4 is a ubiquitously expressed protein. Alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. (NCI)

Synonyms: X-Ray Repair Cross Complementing Protein 4, DNA Double-Strand Break Repair and V(D)J Recombination Protein XRCC4, DNA Repair Protein XRCC4, X-Ray Repair, Complementing Defective, Repair In Chinese Hamster, XRCC4

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