Nutrtion Guide Home > NCI Cancer Thesaurus > X-Ray Repair Cross Complementing Protein-1

X-Ray Repair Cross Complementing Protein-1
Definition and Synonyms

Definition: X-Ray Repair Cross Complementing Protein 1 (XRCC1), encoded by the XRCC1 gene, functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Synonyms: X-Ray Repair Cross Complementing Protein 1, DNA Repair Protein XRCC1, RCC, X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1, X-Ray-Repair, Complementing Defective, Repair In Chinese Hamster, XRCC1

To search for X-Ray Repair Cross Complementing Protein-1 on the web, just click the search button below.

Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.

A | B | C | D | E | F | G | H | I | J | K | L | M
N | O | P | Q | R | S | T | U | V | W | X | Y | Z