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Xeroderma Pigmentosum Complementation Group-A Protein
Definition and Synonyms

Definition: DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein encoded by the XPA gene, has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.

Synonyms: Xeroderma Pigmentosum Complementation Group A Protein, XPA, Xeroderma Pigmentosum Group A Complementing Protein

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