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ZNF151 Gene
Definition and Synonyms

Definition: Human oncogene ZNF151 Gene (Kruppel Family) at 1p36.2-p36.1 encodes Zinc Finger Protein 151, highly expressed in brain and muscle and containing an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Located mainly in the cytosol, ZNF151 exerts a potent growth arrest function that may involve transcriptional activation of growth inhibitory genes; cells progress into S phase but not into mitosis. ZNF151 is regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton. ZNF151 can transactivate the cyclin D1 (CCND1) promoter and activates alpha-2 integrin and LDLR transcription. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest. (OMIM, Swiss-Prot, LocusLink and NCI)

Synonyms: ZNF151 Gene, MIZ1, ZNF151, Zinc Finger Protein 151 Gene

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