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XCR1 Gene
Definition and Synonyms

Definition: Human XCR1 Gene (GPCR Family 1) at 3p21.3-p21.1 encodes within a single exon a 333-amino acid seven transmembrane protein, Chemokine (C Motif) XC Receptor 1, most closely related to RBS11 and MIP1-alpha/RANTES receptor. Strong expression of a 5 kb transcript occurs in placenta, spleen, and thymus. GPR5 is a receptor for chemokines XCL1 (SCYC1) and XCL2 (SCYC2). Cells expressing GPR5 mobilize intracellular calcium and migrate in response to SCYC1 and SCYC2. Migration is suppressed by pertussis toxin, indicating that the receptor is coupled to a G-alpha protein. (Omim, Swiss-Prot, LocusLink, and NCI)

Synonyms: XCR1 Gene, CCXCR1, GPR5, XCR1

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