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ABI2 Gene
Definition and Synonyms

Definition: The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. The ABI-2 gene encodes a protein that is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. The ABI-2 gene is located at chromosome 2q31-q33. (From LocusLink, OMIM)

Synonyms: ABI2 Gene, ABI-2, ABI2, ABI2B, AIP-1, AblBP3, argBPIA

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