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Zinc Finger Protein-147
Definition and Synonyms

Definition: Encoded by human ZNF147 Gene (TRIM Family, RING Finger Family), the ubiquitous 630-amino acid 71 kD cytoplasmic estrogen-responsive Zinc Finger Protein 147 has potential DNA-binding and dimerization-transactivation domains, which suggest that ZNF147 may act as a transcription factor similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from Swiss-Prot, LocusLink, OMIM, and NCI)

Synonyms: Zinc Finger Protein 147, EFP, Estrogen-Responsive Finger Protein, TRIM25, Tripartite Motif Protein TRIM25, Tripartite Motif-Containing 25, Z147, ZNF147, Zinc Finger Protein-147

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