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S100 Calcium Binding Protein-A2
Definition and Synonyms

Definition: Encoded by human S100A2 Gene, 97-amino acid 11 kD S-100L Protein is a member of the S100 Family of cell specific Ca2+-binding proteins containing EF-hand calcium-binding motifs. Induced by growth factors in early G1 and probably by cell-cycle regulation in S phase, S100A2 is preferentially expressed in mammary epithelia and in keratinocytes. S100 proteins are cytoplasmic or nuclear and involved in regulation of cell cycle progression and differentiation. Containing two EF-hand calcium-binding domains, S100 Calcium-Binding Protein A2 interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation in mammary epithelial cells. Altered expression of S100A2 has been implicated in breast cancer. (from Swiss-Prot, OMIM, and NCI)

Synonyms: S100 Calcium Binding Protein A2, CAN19, S-100L Protein, S100 Calcium-Binding Protein A2, S100A2

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