Nutrtion Guide Home > NCI Cancer Thesaurus > ICAM3 Gene

ICAM3 Gene
Definition and Synonyms

Definition: Human ICAM3 Gene at 19p13.3-p13.2 encodes Intercellular Adhesion Molecule 3, a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response. ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains. (from OMIM 146631 and NCI)

Synonyms: ICAM3 Gene, CD50, ICAM3

To search for ICAM3 Gene on the web, just click the search button below.

Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.

A | B | C | D | E | F | G | H | I | J | K | L | M
N | O | P | Q | R | S | T | U | V | W | X | Y | Z