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ZNF147 Gene
Definition and Synonyms

Definition: Within 300 kb of MPO, human ZNF147 Gene (TRIM Family, RING Finger Family) at 17q23.1 encodes a ubiquitous cytoplasmic estrogen-responsive Zinc Finger Protein 147. Gene expression is up regulated via a 3-prime UTR ERE. Putative DNA-binding and dimerization-transactivation domains suggest ZNF147 to be a transcription factor, similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from LocusLink 7706, Swiss-Prot Q14258, OMIM 600453, and NCI)

Synonyms: ZNF147 Gene, EFP Gene, Estrogen-Responsive Finger Protein Gene, ZNF147, Zinc Finger Protein 147 Gene

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