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S100A2 Gene
Definition and Synonyms

Definition: Clustered with at least twelve S100 genes, human S100A2 Gene at 1q21 encodes S-100L Protein, a S100 Family EF-hand cell-specific Ca2+-binding protein. S100A1, closest to the telomere, and S100A1 are located within 450 kb; S100A9 is nearest the centromere. Preferentially expressed in mammary epithelia and keratinocytes, DNA methylation may suppress S100A2; expression is induced by growth factors in G1 and by cell-cycle regulation in S phase. Cytoplasmic and nuclear S100 proteins regulate cell cycle progression and differentiation. Containing two EF-hand domains, S-100L Protein interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation. S100A2 levels correlate inversely with tumor progression. Chromosomal rearrangements and altered expression of S100A2 have been implicated in breast cancer. (from LocusLink 6273, Swiss-Prot P29034, OMIM 176993, and NCI)

Synonyms: S100A2 Gene, S100 Calcium-Binding Protein A2 Gene, S100A2, S100L Gene

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