Nutrtion Guide Home > NCI Cancer Thesaurus > ABCG2 Gene

ABCG2 Gene
Definition and Synonyms

Definition: Highly expressed in the placenta, the human ABCG2 gene (ABC family) at 4q22 makes two transcripts differing at the 5-prime end that encode the same protein. The promoter has a CCAAT box but lacks a TATA box. The ATP Binding Cassette Transporter G2 Protein functions as a membrane-associated homodimeric or homooligomeric xenobiotic transporter in multi-drug resistance. ATP-binding cassette membrane transporters comprise one of the largest protein classes known and are involved in trafficking biologic molecules across extra- and intracellular membranes. ABC genes are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (ABCG). Multidrug-resistant human breast cancer and colon carcinoma cells express an ABCG2 mRNA that confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces intracellular anthracycline and daunorubicin accumulation, and causes an ATP-dependent enhancement of rhodamine-123 efflux. (NCI)

Synonyms: ABCG2 Gene, ABC15, ABCG2, ABCP, ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 Gene, BCRP, BCRP1, BMDP, EST157481, MRX, MXR, MXR1

To search for ABCG2 Gene on the web, just click the search button below.

Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.

A | B | C | D | E | F | G | H | I | J | K | L | M
N | O | P | Q | R | S | T | U | V | W | X | Y | Z