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FABP3 Gene
Definition and Synonyms

Definition: Human FABP3 Gene (FABP/P2/CRBP/CRABP Transporter Family), an open reading frame of 399 nucleotides in four exons over 8 kb at 1p33-p31, encodes a 14-15 kD Fatty Acid-Binding Protein 3 of 133 amino acids. Cytoplasmic FABPs in liver, heart, intestine, skeletal muscle, and brain transport intracellular hydrophobic compounds involved in uptake, metabolism, or transport of long-chain fatty acids and their acyl-CoA esters. Mammalian fatty acid metabolism depends on fatty acid flux between plasma membrane and mitochondria or peroxisomes for beta-oxidation and between other cellular organelles for lipid synthesis. A candidate tumor suppressor for human breast cancer, FABP3 is likely involved in intracellular fatty acid transport, arrests the growth of mammary epithelial cells, and is involved in mammary gland differentiation. (from LocusLink 2170, Swiss-Prot P05413, OMIM 134651, and NCI)

Synonyms: FABP3 Gene, FABP11, FABP3, Fatty Acid-Binding Protein 3 Gene, HFABP, MDGI, MDGI Gene, MFABP, O-FABP

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