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XAF1 Gene
Definition and Synonyms

Definition: Widely expressed as 3.9-, 4.5-, 6.0-, and 7.0-kb transcripts (highest in heart, ovary; lowest in brain, testis) single-copy 7-exon 18-kb human XAF1 Gene (IAP Family) encodes 317-aa 37-kDa XIAP-Associated Factor 1, containing 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)

Synonyms: HSXIAPAF1 Gene, HSXIAPAF1, XAF1, XIAP-Associated Factor 1 Gene

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