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XPA Gene
Definition and Synonyms

Definition: The XPA gene at chromosome 9q22.3 encodes DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein that has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.

Synonyms: XPA Gene, XP, Group A, XP, Group A Gene, XP1, XP1 Gene, XPA, XPA Complementing Gene, XPA Correcting Gene, XPAC, XPAC Gene, Xeroderma Pigmentosum I Gene, Xeroderma Pigmentosum, Complementation Group A Gene

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