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SAFB Gene
Definition and Synonyms

Definition: Human SAFB Gene at 19p13.3-p13.2 encodes HET Scaffold Attachment Factor B, a highly charged monomeric 915-amino acid protein with high S/MAR DNA-binding specificity. A 3.4 kb transcript is widely seen. The protein contains putative phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in loop domains fixed through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFA, -B, -C, and -D interact with S/MAR DNA. SAFB is also an HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM 602895 and NCI)

Synonyms: SAFB Gene, HAP, HET Gene, HET/SAF-B Gene, HET/SAFB Gene, Hsp27-ERE-TATA-Binding Protein Gene, SAF-B, SAFB, Scaffold Attachment Factor B Gene

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